Predicting Treatment Response with Sensory Phenotyping in Post-Traumatic Neuropathic Pain.

ABSTRACT:

Objective

Currently available treatments for neuropathic pain are only modestly efficacious when assessed in randomized clinical trials and work for only some patients in the clinic. Induced-pain or gain-of-function phenotypes have been shown to predict response to analgesics (vs placebos) in patients with neuropathic pain. However, the predictive value of these phenotypes has never been studied in post-traumatic neuropathic pain.

Methods

Mixed-effects models for repeated measures were used to evaluate the efficacy of pregabalin vs placebo in subgroups with induced-pain phenotypes (i.e., hyperalgesia or allodynia) in data from a recent, multinational randomized clinical trial (N = 539) that identified phenotypic subgroups through the use of a structured clinical exam.

Res

SUBMITTER: Gewandter JS 

PROVIDER: S-EPMC9527609 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature