Use of statins after liver transplantation is associated with improved survival: results of a nationwide study.

ABSTRACT:

Background

There is limited information on the effects of statins on the outcomes of liver transplantation (LT), regarding either their use by LT recipients or donors.

Aim

To analyse the association between statin exposure and recipient and graft survival.

Methods

We included adult LT recipients with deceased donors in a nationwide prospective database study. Using a multistate modelling approach, we examined the effect of statins on the transition hazard between LT, biliary and vascular complications and death, allowing for recurring events. The observation time was 3 years.

Results

We included 998 (696 male, 70%, mean age 54.46 ± 11.14 years) LT recipients. 14% of donors and 19% of recipients were exposed to statins during the study period. During follow-up,

SUBMITTER: Becchetti C 

PROVIDER: S-EPMC9545989 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature