Air pollution and dementia in older adults in the Ginkgo Evaluation of Memory Study.

ABSTRACT:

Introduction

Growing evidence implicates air pollution as a risk factor for dementia, but prior work is limited by challenges in diagnostic accuracy and assessing exposures in the decades prior to disease development. We evaluated the impact of long-term fine particulate matter (PM_2.5 ) exposures on incident dementia (all-cause, Alzheimer's disease [AD], and vascular dementia [VaD]) in older adults.

Methods

A panel of neurologists adjudicated dementia cases based on extensive neuropsychological testing and magnetic resonance imaging. We applied validated fine-scale air pollutant models to reconstructed residential histories to assess exposures.

Results

An interquartile range increase in 20-year PM_2.5 was associated with a 20% higher risk of demen

SUBMITTER: Semmens EO 

PROVIDER: S-EPMC9576823 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature