Functionalized Ultrasmall Iron Oxide Nanoparticles for T₁-Weighted Magnetic Resonance Imaging of Tumor Hypoxia.

ABSTRACT: Hypoxia is a common biological condition in many malignant solid tumors that plays an imperative role in regulating tumor growth and impacting the treatment's therapeutic effect. Therefore, the hypoxia assessment is of great significance in predicting tumor development and evaluating its prognosis. Among the plenty of existing tumor diagnosis techniques, magnetic resonance imaging (MRI) offers certain distinctive features, such as being free of ionizing radiation and providing images with a high spatial resolution. In this study, we develop a fluorescent traceable and hypoxia-sensitive T₁-weighted MRI probe (Fe₃O₄-Met-Cy5.5) via conjugating notable hypoxia-sensitive metronidazole moiety and Cy5.5 dye with ultrasmall iron oxide (Fe₃O_4<

SUBMITTER: Yang L 

PROVIDER: S-EPMC9610745 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature