Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment.

ABSTRACT: Diabetic wounds have poor healing outcomes due to the presence of numerous pathogens and a dysregulated immune response. Group B Streptococcus (GBS) is commonly isolated from diabetic wound infections, but the mechanisms of GBS virulence during these infections have not been investigated. Here, we develop a murine model of GBS diabetic wound infection and, using dual RNA sequencing, demonstrate that GBS infection triggers an inflammatory response. GBS adapts to this hyperinflammatory environment by up-regulating virulence factors including those known to be regulated by the two-component system covRS, such as the surface protein pbsP, and the cyl operon, which is responsible for hemolysin/pigmentation production. We recover hyperpigmented/hemolytic GBS colonies

SUBMITTER: Keogh RA 

PROVIDER: S-EPMC9651866 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature