Ontology highlight
ABSTRACT:
SUBMITTER: Fuh-Ngwa V
PROVIDER: S-EPMC9652373 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Fuh-Ngwa Valery V Zhou Yuan Y Melton Phillip E PE van der Mei Ingrid I Charlesworth Jac C JC Lin Xin X Zarghami Amin A Broadley Simon A SA Ponsonby Anne-Louise AL Simpson-Yap Steve S Lechner-Scott Jeannette J Taylor Bruce V BV
Scientific reports 20221111 1
Limited studies have been conducted to identify and validate multiple sclerosis (MS) genetic loci associated with disability progression. We aimed to identify MS genetic loci associated with worsening of disability over time, and to develop and validate ensemble genetic learning model(s) to identify people with MS (PwMS) at risk of future worsening. We examined associations of 208 previously established MS genetic loci with the risk of worsening of disability; we learned ensemble genetic decisio ...[more]