Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis.
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ABSTRACT:
SUBMITTER: Devolder L
PROVIDER: S-EPMC9980703 | biostudies-literature | 2023 Jan-Dec
REPOSITORIES: biostudies-literature
Publications
Gut microbiome composition is associated with long-term disability worsening in multiple sclerosis.
Devolder Lindsay L Pauwels Ayla A Van Remoortel Ann A Falony Gwen G Vieira-Silva Sara S Nagels Guy G De Keyser Jacques J Raes Jeroen J D'Hooghe Marie B MB
Gut microbes 20230101 1
Predicting the long-term outcome of multiple sclerosis (MS) remains an important challenge to this day. As the gut microbiota is emerging as a potential player in MS, we investigated in this study whether gut microbial composition at baseline is related to long-term disability worsening in a longitudinal cohort of 111 MS patients. Fecal samples and extensive host metadata were collected at baseline and 3 months post-baseline, with additional repeated neurological measurements performed over (med ...[more]
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