Metabolic connectivity is associated with seizure outcome in surgically treated temporal lobe epilepsies: A ¹⁸F-FDG PET seed correlation analysis.

ABSTRACT: ¹⁸F-FDG PET provides high sensitivity for the pre-surgical assessment of drug-resistant temporal lobe epilepsy (TLE). However, little is known about the metabolic connectivity of epileptogenic networks involved. This study therefore aimed to evaluate the association between metabolic connectivity and seizure outcome in surgically treated TLE.

Methods

The study included 107 right-handed patients that had undergone a presurgical interictal ¹⁸F-FDG PET assessment followed by an anterior temporal lobectomy and were classified according to seizure outcome 2 years after surgery. Metabolic connectivity was evaluated by seed correlation analysis in left and right epilepsy patients with a Class Engel IA or > IA outcome and compared to age-, sex- and handedness-matched h

SUBMITTER: Doyen M 

PROVIDER: S-EPMC9668618 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature