Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples.

ABSTRACT: Severe COVID-19 causes profound immune perturbations, but pre-infection immune signatures contributing to severe COVID-19 remain unknown. Genome-wide association studies (GWAS) identified strong associations between severe disease and several chemokine receptors and molecules from the type I interferon pathway. Here, we define immune signatures associated with severe COVID-19 using high-dimensional flow cytometry. We measure the cells of the peripheral immune system from individuals who recovered from mild, moderate, severe or critical COVID-19 and focused only on those immune signatures returning to steady-state. Individuals that suffered from severe COVID-19 show reduced frequencies of T cell, mucosal-associated invariant T cell (MAIT) and dendritic cell (DC) subsets and altered chemokin

SUBMITTER: Liechti T 

PROVIDER: S-EPMC9700777 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature