Neurodevelopmental patterns of early postnatal white matter maturation represent distinct underlying microstructure and histology.

ABSTRACT: Cerebral white matter undergoes a rapid and complex maturation during the early postnatal period. Prior magnetic resonance imaging (MRI) studies of early postnatal development have often been limited by small sample size, single-modality imaging, and univariate analytics. Here, we applied nonnegative matrix factorization, an unsupervised multivariate pattern analysis technique, to T₂w/T₁w signal ratio maps from the Developing Human Connectome Project (n = 342 newborns) revealing patterns of coordinated white matter maturation. These patterns showed divergent age-related maturational trajectories, which were replicated in another independent cohort (n = 239). Furthermore, we showed that T₂w/T₁w signal variations in these maturational patterns are

SUBMITTER: Nazeri A 

PROVIDER: S-EPMC9742299 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature