Comparative genomic analysis of plasmids harboring bla _OXA-48-like genes in Klebsiella pneumoniae.

ABSTRACT: The emergence and spread of carbapenem-resistant Klebsiella pneumoniae (CRKP) is a serious medical problem worldwide. Acquired OXA-48-like carbapenemases encoded by plasmids are important causes of carbapenem resistance in K. pneumoniae. To explore the links between plasmids and bla _OXA-48-like genes in K. pneumoniae, we systematically analyzed the variants of bla _OXA-48-like plasmid replicon types, phylogenetic patterns, geographic distribution, conjugative transfer regions, and the genetic environments surrounding bla _OXA-48-like of 191 bla _OXA-48-like-harboring plasmids, which were identified from 4451 plasmids of K. pneumoniae downloaded from GenBank. Our results showed that seven differ

SUBMITTER: Li W 

PROVIDER: S-EPMC9807924 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature