In silico characterization of bla _NDM-harboring plasmids in Klebsiella pneumoniae.

ABSTRACT: Klebsiella pneumoniae is a primary culprit of antibiotic-resistant nosocomial infections worldwide, and infections caused by NDM-producing strains are a major threat due to limited therapeutic options. The majority of bla _NDM cases occur on plasmids; therefore, we explored the relationships between plasmids and bla _NDM genes in K. pneumoniae by analyzing the variants of bla _NDM, replicon types, conjugative transfer regions of 171 bla _NDM-harboring plasmids from 4,451 K. pneumoniae plasmids. Of the nine identified bla _NDM variants, bla _NDM-1 (73.68%) and bla _NDM-5 (16.37%) were the most dominant. Over half of the bla _NDM-harbori

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC9727287 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature