Association of several loci of SMAD7 with colorectal cancer: A meta-analysis based on case-control studies.

ABSTRACT:

Background

Sma-and mad-related protein 7 (SMAD7) can affect tumor progression by closing transforming growth factor-beta intracellular signaling channels. Despite the extensive research on the correlation between SMAD7 polymorphisms and colorectal cancer (CRC), the conclusions of studies are still contradictory. We conducted a study focusing on the association of SMAD7 polymorphisms rs4939827, rs4464148, and rs12953717 with CRC.

Methods

We searched through 5 databases for articles and used odd ratios (ORs) and 95% confidence intervals (CIs) to discuss the correlation of SMAD7 polymorphisms with CRC risk. The heterogeneity will be appraised by subgroup analysis and meta-regression. Contour-enhanced funnel plot, Begg test and Egger test were utilized to estimate publication bi

SUBMITTER: Xiao Q 

PROVIDER: S-EPMC9829263 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature