Amide directed iridium C(sp³)-H borylation catalysis with high N-methyl selectivity.

ABSTRACT: A bidentate monoanionic ligand system was developed to enable iridium catalyzed C(sp³)-H activation borylation of N-methyl amides. Borylated amides were obtained in moderate to good isolated yields, and exclusive mono-borylation allowed the amide to be the limiting reagent. Selectivity for C(sp³)-H activation was demonstrated in the presence of sterically available C(sp³)-H bonds. Competitive kinetic isotope studies revealed a large primary isotope effect, implicating C-H activation as the rate limiting step.

SUBMITTER: Dannatt JE 

PROVIDER: S-EPMC9854009 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature