Accelerating corneal wound healing using exosome-mediated targeting of NF-κB c-Rel.

ABSTRACT: The integrity of the corneal epithelium is essential for the maintenance of the physiological function of the cornea. Studies have found that inflammation greatly delays corneal wound healing. NF-κB c-Rel is preferentially expressed by immune cells and promotes the expression of inflammatory cytokines. In the current study, we sought to investigate whether c-Rel could be used as a potential therapeutic target for treating a corneal injury. Our studies reveal that expressions of c-Rel and its inflammatory targets are significantly increased in the cornea of mice with corneal injury. In addition, we find that c-Rel-deficient mice exhibit accelerated corneal wound healing and reduced expression of inflammatory cytokines. Further studies show that topical treatment on the corneal surface using

SUBMITTER: Zhao W 

PROVIDER: S-EPMC9881367 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature