Association between periodontitis and COVID-19 infection: a two-sample Mendelian randomization study.

ABSTRACT:

Background and objective

Epidemiological studies report associations between coronavirus disease 2019 (COVID-19) and periodontitis; however, causality has not been proven. The aim of this study is to assess the associations between COVID-19 susceptibility and periodontitis with two-sample Mendelian randomization (MR) analyses.

Methods

A two-sample summary MR analysis was performed using data for outcome and exposure from the OpenGWAS database on people of European descent. Periodontal complex traits (PCTs) were chosen as a proxy for the periodontitis phenotype. The causal association between PCT3 (Aggregatibacter actinomycetemcomitans), PCT5 (Porphyromonas gingivalis), and gingival crevicular fluid (GCF) interleukin-1β (IL-1β) and COVID-19 were co

SUBMITTER: Meng Z 

PROVIDER: S-EPMC9884046 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature