Dataset Information

Ulcerative colitis increases risk of hypertension in a UK biobank cohort study.

ABSTRACT:

Objective

Inflammatory bowel disease (IBD) is not only a chronic inflammatory disorder of the gastrointestinal tract but also accompanied by systemic inflammation. The onset of hypertension is closely related to systemic inflammation. However, the relationship between IBD and hypertension has not been investigated. We aimed to investigate the potential association between IBD and the incidence of hypertension.

Method

We retrieved IBD onset and the incidence of hypertension from a public database UK Biobank. The association between the onset of IBD and subsequent incidence of hypertension was analyzed using a multivariate Cox regression analysis, and propensity score matching was performed for sensitivity analysis.

Result

Of a total of 281,064 participants included in the study, 2376 (0.8%) were diagnosed with IBD at baseline, and 20,129 (7.2%) in the whole cohort developed hypertension with a median follow-up duration of 8.1 years (interquartile range [IQR] 7.3-8.8 years). Patients with IBD had a higher cumulative risk of hypertension compared with general population (10.9% in ulcerative colitis [UC], 7.7% in Crohn's disease [CD], and 9.3% in IBD unclassified [IBD-U] vs. 7.1% in non-IBD, p < 0.001). Multivariate Cox regression analysis identified that UC, rather than CD or IBD-U, was independently associated with subsequent occurrence of hypertension (HR 1.30, 95% CI: 1.11-1.52, p = 0.001). In propensity matching analysis, UC also showed its robustness as a risk factor for the prediction of hypertension (HR 1.56, 95% CI: 1.21-2.03, p = 0.001).

Conclusion

In IBD patients, UC rather than CD is associated with a higher risk for the incidence of hypertension compared with general population. Close monitoring of hypertension might be required in clinical practice.

SUBMITTER: He J

PROVIDER: S-EPMC9892434 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Ulcerative colitis increases risk of hypertension in a UK biobank cohort study.

He Jinshen J Zhang Shaozhao S Qiu Yun Y Liu Fen F Liu Zishan Z Tan Jinyu J Hu Fan F Wu Xiaomin X Wang Yu Y Zhou Longyuan L Hu Shixian S Chen Minhu M Liao Xinxue X Zhuang Xiaodong X Mao Ren R

United European gastroenterology journal 20221212 1

<h4>Objective</h4>Inflammatory bowel disease (IBD) is not only a chronic inflammatory disorder of the gastrointestinal tract but also accompanied by systemic inflammation. The onset of hypertension is closely related to systemic inflammation. However, the relationship between IBD and hypertension has not been investigated. We aimed to investigate the potential association between IBD and the incidence of hypertension.<h4>Method</h4>We retrieved IBD onset and the incidence of hypertension from a ...[more]

PMID: 36507867

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Dataset Information

Ulcerative colitis increases risk of hypertension in a UK biobank cohort study.

Objective

Method

Result

Conclusion

Publications

Ulcerative colitis increases risk of hypertension in a UK biobank cohort study.

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