Dataset Information

[¹⁸F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study.

ABSTRACT:

Purpose

Meta-[¹⁸F]fluorobenzylguanidine ([¹⁸F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging of tumours expressing the norepinephrine transporter. This pilot study investigates the feasibility of [¹⁸F]mFBG PET-CT for imaging in neuroblastoma.

Methods

In a prospective, single-centre study, we recruited children with neuroblastoma, referred for meta-[¹²³I]iodobenzylguanidine ([¹²³I]mIBG) scanning, consisting of total body planar scintigraphy in combination with single-photon emission computed tomography-CT (SPECT-CT). Within two weeks of [¹²³I]mIBG scanning, total body PET-CTs were performed at 1 h and 2 h after injection of [¹⁸F]mFBG (2 MBq/kg). Detected tumour localisations on scan pairs were compared. Soft tissue disease was quantified by number of lesions and skeletal disease by SIOPEN score.

Results

Twenty paired [¹²³I]mIBG and [¹⁸F]mFBG scans were performed in 14 patients (median age 4.9 years, n = 13 stage 4 disease and n = 1 stage 4S). [¹⁸F]mFBG injection was well tolerated and no related adverse events occurred in any of the patients. Mean scan time for [¹⁸F]mFBG PET-CT (9.0 min, SD 1.9) was significantly shorter than for [¹²³I]mIBG scanning (84.5 min, SD 10.5), p < 0.01. Most tumour localisations were detected on the 1 h versus 2 h post-injection [¹⁸F]mFBG PET-CT. Compared to [¹²³I]mIBG scanning, [¹⁸F]mFBG PET-CT detected a higher, equal, and lower number of soft tissue lesions in 40%, 55%, and 5% of scan pairs, respectively, and a higher, equal, and lower SIOPEN score in 55%, 30%, and 15% of scan pairs, respectively. On average, two more soft tissue lesions and a 6-point higher SIOPEN score were detected per patient on [¹⁸F]mFBG PET-CT compared to [¹²³I]mIBG scanning.

Conclusion

Results of this study demonstrate feasibility of [¹⁸F]mFBG PET-CT for neuroblastoma imaging. More neuroblastoma localisations were detected on [¹⁸F]mFBG PET-CT compared to [¹²³I]mIBG scanning. [¹⁸F]mFBG PET-CT shows promise for future staging and response assessment in neuroblastoma.

Trial registration

Dutch Trial Register NL8152.

SUBMITTER: Samim A

PROVIDER: S-EPMC9931849 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

[<sup>18</sup>F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study.

Samim Atia A Blom Thomas T Poot Alex J AJ Windhorst Albert D AD Fiocco Marta M Tolboom Nelleke N Braat Arthur J A T AJAT Viol Sebastiaan L Meyer SLM van Rooij Rob R van Noesel Max M MM Lam Marnix G E H MGEH Tytgat Godelieve A M GAM de Keizer Bart B

European journal of nuclear medicine and molecular imaging 20221212 4

<h4>Purpose</h4>Meta-[<sup>18</sup>F]fluorobenzylguanidine ([<sup>18</sup>F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging of tumours expressing the norepinephrine transporter. This pilot study investigates the feasibility of [<sup>18</sup>F]mFBG PET-CT for imaging in neuroblastoma.<h4>Methods</h4>In a prospective, single-centre study, we recruited children with neuroblastoma, referred for meta-[<sup>123</sup>I]iodobenzylguanidine ([<su ...[more]

PMID: 36504277

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Dataset Information

[¹⁸F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study.

Purpose

Methods

Results

Conclusion

Trial registration

Publications

[<sup>18</sup>F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study.

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Dataset Information

[18F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study.

Purpose

Methods

Results

Conclusion

Trial registration

Publications

[<sup>18</sup>F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

[¹⁸F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study.