[¹⁸F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study.

ABSTRACT:

Purpose

Meta-[¹⁸F]fluorobenzylguanidine ([¹⁸F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging of tumours expressing the norepinephrine transporter. This pilot study investigates the feasibility of [¹⁸F]mFBG PET-CT for imaging in neuroblastoma.

Methods

In a prospective, single-centre study, we recruited children with neuroblastoma, referred for meta-[¹²³I]iodobenzylguanidine ([¹²³I]mIBG) scanning, consisting of total body planar scintigraphy in combination with single-photon emission computed tomography-CT (SPECT-CT). Within two weeks of [¹²³I]mIBG scanning, total body PET-CTs were performed at 1 h and 2 h after injection of [¹⁸F]mFBG (2 MBq/

SUBMITTER: Samim A 

PROVIDER: S-EPMC9931849 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature