EGFR promotes the apoptosis of CD4⁺ T lymphocytes through TBK1/Glut1 induced Warburg effect in sepsis.

ABSTRACT:

Introduction

Sepsis-induced apoptosis leads to lymphopenia including the decrease of CD4⁺ T cells thus favoring immunosuppression.

Objectives

Although epidermal growth factor receptor (EGFR) inhibitors significantly improve the survival rate of septic mice, the effect of EGFR on the function and metabolism of CD4⁺ T cells in sepsis remained unknown.

Methods

CD4⁺ T cells from septic mice and patients were assessed for apoptosis, activation, Warburg metabolism and glucose transporter 1 (Glut1) expression with or without the interference of EGFR activation.

Results

EGFR facilitates CD4⁺ T cell activation and apoptosis through Glut1, which is a key enzyme that controls glycolysis in T cells. EGFR, TANK binding kinase 1 (T

SUBMITTER: Huang L 

PROVIDER: S-EPMC9936423 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature