POLITAG-M-F as Heterogeneous Organocatalyst for the Waste-Minimized Synthesis of β-Azido Carbonyl Compounds in Batch and under Flow Conditions.

ABSTRACT: We herein report a waste minimization protocol for the β-azidation of α,β-unsaturated carbonyl compounds using TMSN₃. The selection of the appropriate catalyst (POLITAG-M-F), in combination with the reaction medium, resulted in enhanced catalytic efficiency and a low environmental footprint. The thermal and mechanical stability of the polymeric support allowed us to recover the POLITAG-M-F catalyst for up to 10 consecutive runs. The CH₃CN:H₂O azeotrope has a 2-fold positive effect on the process, increasing the efficiency of the protocol and minimizing waste generation. Indeed, the azeotropic mixture, used as a reaction medium and for the workup procedure, was recovered by distillation, leading to an easy and environmentally friendly procedure

SUBMITTER: Valentini F 

PROVIDER: S-EPMC9945162 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature