PET Imaging of Hepatocellular Carcinoma Using ZD2-(⁶⁸Ga-NOTA).

ABSTRACT:

Purpose

We tested a recently developed short peptide radioligand for PET imaging of hepatocellular carcinoma (HCC) by targeting an oncoprotein, extra-domain B fibronectin (EDB-FN) in the tumor microenvironment.

Methods

The radioligand consists of a small linear peptide ZD2 with ⁶⁸Ga-NOTA chelator, and specifically binds to EDB-FN. PET images were acquired dynamically for 1 hour after intravenously (i.v.) injecting 37 MBq (1.0 mCi) of the radioligand into the woodchuck model of naturally occurring HCC. Woodchuck HCC originated from chronic viral hepatitis infection, which recapitulates the corresponding human primary liver cancer. The animals were euthanized post-imaging for tissue collection and validation.

Results

For ZD2 avid liver tumors, the radioligand

SUBMITTER: Sergeeva O 

PROVIDER: S-EPMC9968869 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature