Dataset Information

Multimodal Brain MRI of Deep Gray Matter Changes Associated With Inflammatory Bowel Disease.

ABSTRACT:

Background

Behavioral symptoms, including mood disorders, substantially impact the quality of life of patients with inflammatory bowel disease (IBD), even when clinical remission is achieved. Here, we used multimodal magnetic resonance imaging (MRI) to determine if IBD is associated with changes in the structure and function of deep gray matter brain regions that regulate and integrate emotional, cognitive, and stress responses.

Methods

Thirty-five patients with ulcerative colitis (UC) or Crohn's disease (CD) and 32 healthy controls underwent 3 Tesla MRIs to assess volume, neural activity, functional connection strength (connectivity), inflammation, and neurodegeneration of key deep gray matter brain regions (thalamus, caudate, pallidum, putamen, amygdala, hippocampus, and hypothalamus) involved in emotional, cognitive and stress processing. Associations with sex, presence of pain, disease activity, and C-reactive protein (CRP) concentration were examined.

Results

Significantly increased activity and functional connectivity were observed in cognitive and emotional processing brain regions, including parts of the limbic system, basal ganglia, and hypothalamus of IBD patients compared with healthy controls. Inflammatory bowel disease patients exhibited significantly increased volumes of the amygdala and hypothalamus, as well as evidence of neurodegeneration in the putamen and pallidum. Hippocampal neural activity was increased in IBD patients with active disease. The volume of the thalamus was positively correlated with CRP concentration and was increased in females experiencing pain.

Conclusions

Patients with IBD exhibit functional and structural changes in the limbic and striatal systems. These changes may be targets for assessing or predicting the response to therapeutic interventions aimed at improving comorbid emotional and cognitive symptoms.

SUBMITTER: Goodyear BG

PROVIDER: S-EPMC9977255 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

Multimodal Brain MRI of Deep Gray Matter Changes Associated With Inflammatory Bowel Disease.

Goodyear Bradley G BG Heidari Faranak F Ingram Richard J M RJM Cortese Filomeno F Sharifi Nastaran N Kaplan Gilaad G GG Ma Christopher C Panaccione Remo R Sharkey Keith A KA Swain Mark G MG

Inflammatory bowel diseases 20230301 3

<h4>Background</h4>Behavioral symptoms, including mood disorders, substantially impact the quality of life of patients with inflammatory bowel disease (IBD), even when clinical remission is achieved. Here, we used multimodal magnetic resonance imaging (MRI) to determine if IBD is associated with changes in the structure and function of deep gray matter brain regions that regulate and integrate emotional, cognitive, and stress responses.<h4>Methods</h4>Thirty-five patients with ulcerative colitis ...[more]

PMID: 35590449

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Dataset Information

Multimodal Brain MRI of Deep Gray Matter Changes Associated With Inflammatory Bowel Disease.

Background

Methods

Results

Conclusions

Publications

Multimodal Brain MRI of Deep Gray Matter Changes Associated With Inflammatory Bowel Disease.

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