Longitudinal DAT changes measured with [¹⁸F]FE-PE2I PET in patients with Parkinson's disease; a validation study.

ABSTRACT:

Background

Dopamine transporter (DAT) PET provides higher resolution than DAT SPECT and opportunity for integrated imaging with MRI. The radioligand [¹⁸F]FE-PE2I is highly selective for the DAT, and PET measurements with this radioligand have good reliability and repeatability in patients with non-advanced Parkinson's disease.

Objectives

To validate [¹⁸F]FE-PE2I PET as measurement tool of longitudinal DAT changes in patients with Parkinson's disease.

Methods

Thirty-seven subjects with Parkinson's disease (Hoehn and Yahr stage < 3) were included in a longitudinal PET study with [¹⁸F]FE-PE2I. DAT availability (BP_ND) in the caudate nucleus, putamen, sensorimotor striatum, and substantia nigra, was estimated with parametric imag

SUBMITTER: Kerstens VS 

PROVIDER: S-EPMC9978841 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature