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AhmedMobeen2021 - NF-kB Activation Model

ABSTRACT: NF-kappaB Activation Model includes the activation of both NFKB1:RELA and NFKB2:RELB for Canonical and Non-Canonical Pathway respectively.The model includes the pathway model integrated with post-translational modifications of NF-kB subunits that regulate the NFKB1:RELA and NFKB2:RELB activity. The processes that are regulated by NF-kB pathway can be monitored through following readouts NFKB1:RELA Activity, NFKB2:RELB Activity, Degraded RelA, Degraded RelB, Degraded IkB, Degraded NIK, Apoptosis, Tumour, Antiviral Activity, B Cell Growth and Cell Migration. However, last 5 processes above are also influenced by other pathways too, therefore while making predictions, caution has to be exercised.

SUBMITTER: Ahmed Mobeen 

PROVIDER: MODEL2001290001 | biostudies-other |

SECONDARY ACCESSION(S): 10.1002/prot.26388

REPOSITORIES: biostudies-other

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Publications

The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes.

Jones Gillian G GG   Reaper Philip M PM   Pettitt Andrew R AR   Sherrington Paul D PD  

Oncogene 20040301 10

Chronic lymphocytic leukaemia (CLL) results from the accumulation of apoptosis-resistant clonal B cells that are arrested in G0/G1, and is heterogeneous with respect to clinical outcome. An aggressive form of the disease is identified by an impaired p53 response to ionizing radiation (IR). This is associated with inactivating mutations of either p53 or ATM, a regulator of p53 activated by IR-induced DNA damage. Since other forms of DNA damage activate p53 via ATR, a kinase closely related to ATM  ...[more]

PMID: 14755251

Publication: 1/368

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