Ontology highlight
ABSTRACT:
SUBMITTER: Jiang GJ
PROVIDER: S-EPMC1688420 | biostudies-other | 1997 May
REPOSITORIES: biostudies-other
Jiang G J GJ Zidanic M M Michaels R L RL Michael T H TH Griguer C C Fuchs P A PA
Proceedings. Biological sciences 19970501 1382
Large conductance, calcium-activated (BK) potassium channels play a central role in the excitability of cochlear hair cells. In mammalian brains, one class of these channels, termed Slo, is encoded by homologues of the Drosophila 'slowpoke' gene. By homology screening with mouse Sla cDNA, we have isolated a full-length clone (cSlo1) from a chick's cochlear cDNA library, rSlol had greater than 90% identity with mouse Slo at the amino acid level, and was even better matched to a human brain Slo at ...[more]