Ontology highlight
ABSTRACT:
SUBMITTER: Hernebring M
PROVIDER: S-EPMC3587881 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Scientific reports 20130101
In embryonic stem cells, removal of oxidatively damaged proteins is triggered upon the first signs of cell fate specification but the underlying mechanism is not known. Here, we report that this phase of differentiation encompasses an unexpected induction of genes encoding the proteasome activator PA28αβ (11S), subunits of the immunoproteasome (20Si), and the 20Si regulator TNFα. This induction is accompanied by assembly of mature PA28-20S(i) proteasomes and elevated proteasome activity. Inhibit ...[more]