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MiRNA expression in Th17 cells after AhR activation

ABSTRACT: Th17 cells play a major role in the pathogenesis of Rheumatoid Arthritis, and it is well known the involvement of the Aryl Hydrocarbon Receptor (AhR) during the differentiation and activation of these cells. Due to its function as a transcription factor, we tested wether AhR would mediate part of its function in Th17 cells through the transcription of microRNAs (miRNAs). Therefore, we first perform a microarray experiment to identify the miRNAs induced after AhR activation in Th17 cells. Under a supervised hierarchical clustering, we identify 224 miRNAs differentially expressed (fold-change ³ 2.0 and FDR < 5%). Among them, 22 miRNAs were up regulated exclusively in Th17 cells in the presence of FICZ.

ORGANISM(S): Mus musculus

PROVIDER: GSE149169 | GEO | 2021/01/27

REPOSITORIES: GEO

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Transcriptome profiles of colonic stem cells of WT and AHR deficient mice treated with either DMSO or high affinity AHR ligand, FICZ for 4 hours

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