INSTRUMENT(S): Lieb Lab at UNC-CH_Yeast Whole-genome Array (PCR-based)_for Buck MJ et al.
SUBMITTER: Jennifer Lynn McCulley
SECONDARY ACCESSION(S): PRJNA119971
Proceedings of the National Academy of Sciences of the United States of America 20100607 25
The human ATM and ATR proteins participate in the DNA damage and DNA replication checkpoint pathways and are critical to maintaining genome stability. The Saccharomyces cerevisiae homologs of ATM and ATR are Tel1p and Mec1p, respectively. Haploid tel1 mec1 strains have very short telomeres and very high rates of chromosomal aberrations. Here, we examine genetic stability in tel1 mec1 diploid cells. In the absence of induced DNA damage, these yeast strains had very high frequencies of aneuploidy ...[more]