Synovial fibroblasts assume distinct functional identities and secrete R‑spondin 2 to drive osteoarthritis

ABSTRACT: Synovium is acutely affected following joint trauma and contributes to post-traumatic osteoarthritis (PTOA) progression. Little is known about discrete cell types and molecular mechanisms in PTOA synovium. We aimed to describe synovial cell populations and their dynamics in PTOA. Single-cell RNA-seq profiling of synovium revealed fibroblasts (comprised of various functional subsets), macrophages, endothelial cells and pericytes to be the predominanent synovial cell types, along with rarer populations including T cells, Schwann cells and mast cells. Cell types undergo profound changes in abundance and gene expression following joint injury.

ORGANISM(S): Mus musculus

PROVIDER: GSE211584 | GEO | 2022/08/25

REPOSITORIES: GEO