Transcriptomics

Dataset Information

0

Decades-long elevation of interferon-alpha can initiate and drive Sjogren syndrome II


ABSTRACT: Sjogren syndrome (SS) is a chronic inflammatory disease with no effective targeted treatments. There is a pressing need to identify targetable pathways which drive disease. Here we combine ultrasensitive detection of IFN-α with proteomic approaches in two cohorts including UK Biobank to demonstrate that IFN-α is elevated in the majority of individuals with SS, and this elevation can precede diagnosis by 15 years and persists for 30 years. We identify a distinct immunological phenotype associated with elevated IFN-α characterised by peripheral blood cytopenias, hypergammaglobulinaemia and SS-specific autoantibody formation. To address a causal role for chronic interferon elevation in initiating and driving these immunological features we created a novel model of systemic chronic IFN-α elevation upon overexpression of Ifna4 in conventional dendritic cells type 1 of mice. This model recapitulates the key IFN-α -associated features we identified in clinical studies and can be effectively treated by IFNAR1-blocking monoclonal antibodies. In summary chronically elevated IFN-α can initiate and drive immunopathological features of SS and represents a therapeutic target.

ORGANISM(S): Mus musculus

PROVIDER: GSE273098 | GEO | 2025/07/02

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2025-07-02 | GSE273095 | GEO
2008-06-19 | E-GEOD-11190 | biostudies-arrayexpress
2012-01-01 | E-GEOD-31187 | biostudies-arrayexpress
2014-01-30 | E-GEOD-48445 | biostudies-arrayexpress
2022-10-05 | GSE168148 | GEO
2008-04-17 | GSE11190 | GEO
2005-10-05 | E-SMDB-1896 | biostudies-arrayexpress
2012-01-01 | GSE31187 | GEO
2006-01-31 | E-GEOD-4134 | biostudies-arrayexpress
2012-06-08 | E-GEOD-38147 | biostudies-arrayexpress