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Pharmacological inhibition of sclerostin protects bone from B-cell acute lymphoblastic leukemia-mediated destruction

ABSTRACT: The cellular components of the BM microenvironment are known to play a role in the development of B-cell acute lymphoblastic leukemia (B-ALL). However, molecular differences between heathy osteoblastic cells (OBCs) and OBCs associated with B-ALL remain unclear. This study utilises bulk RNA-seq to evaluate the molecular signatures between the healthy OBCs and B-ALL-associated OBCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE298870 | GEO | 2026/05/05

REPOSITORIES: GEO

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