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Effects of T cell–specific IL-21 isoform expression on gene expression in mammary epithelial cells.

ABSTRACT: Interleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4⁺ T cells that critically regulates the differentiation and functions of various adaptive and innate immune cells. In this study, to investigate the chronic effects of IL-21 on gene expression in mammary epithelial cells (MECs), MECs were isolated from 10-week-old transgenic mice expressing a membrane-bound IL-21 isoform specifically in T cells (IL-21isoTg) and subjected to RNA sequencing analysis, followed by comparison with wild-type controls. IL-21isoTg MECs showed marked upregulation of genes associated with mammary gland development and lactation and Spp1.

ORGANISM(S): Mus musculus

PROVIDER: GSE331007 | GEO | 2026/05/18

REPOSITORIES: GEO

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