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CEMA, a platform to define cell states

ABSTRACT: gene expression database and algorithm to define cell expression modules Using a newly-generated compendium of cell-state-specific gene expression data, we identified genes that uniquely define each cell state, including those thought to represent various developmental stages. Whereas others have performed similar analyses on tissue-specific, heterogeneous collections of public data, our focus is on single-laboratory, cell-specific data. The approach allows for more refined information than tissues, while single-laboratory data, although fewer in number, minimize artifacts arising from inter-laboratory merging. Our analysis sheds light on human cell fate through the identification of core genes that are altered over several developmental milestones, and across regional specification. Finally, we provide an interactive, web-based application for dissemination and exploration of our results, yielding a valuable resource with a novel perspective on the development of human cells. This web service is available at www.cemagenes.com.

ORGANISM(S): Homo sapiens

PROVIDER: GSE47796 | GEO | 2016/04/12

SECONDARY ACCESSION(S): PRJNA207818

REPOSITORIES: GEO

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