Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Altered epigenetic programming links intestinal inflammation to colon cancer

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE57569 | GEO | 2015/06/17

SECONDARY ACCESSION(S): PRJNA246715

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Altered epigenetic programming links intestinal inflammation to colon cancer

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-06-17 | E-GEOD-57569 | biostudies-arrayexpress

Altered epigenetic programming links intestinal inflammation to colon cancer (Bisulfite-seq)

Project description:This study uses whole-genome bisulfite sequencing to characterize the methylomes of the AOM/DSS mouse model at single-base resolution. In this model, mice are treated with dextran sodium sulfate (DSS) to induce colitis. When this treatment is preceded by injections of the weak carcinogen azoxymethane (AOM) the mice develop intestinal tumors. Our results identify hypermethylated DMVs as a prominent feature of the colitis methylome that is conserved in intestinal adenocarcinomas. Further analyses reveal a subset of DMV-associated genes, expressed in normal intestinal epithelial cells, that were silenced and hypermethylated in inflamed and cancerous intestinal cells. Together, these findings provide strong support for the hypothesis that inflammatory signals induce a higher risk for cancer development by manipulating the epigenome. .

2015-06-17 | GSE57527 | GEO

Altered epigenetic programming links intestinal inflammation to colon cancer (Bisulfite-seq)

2015-06-17 | E-GEOD-57527 | biostudies-arrayexpress

Altered epigenetic programming links intestinal inflammation to colon cancer (RNA-seq)

Project description:This study uses whole-transcriptome sequencing to characterize the transcriptomes of the AOM/DSS mouse model. In this model, mice are treated with dextran sodium sulfate (DSS) to induce colitis. When this treatment is preceded by injections of the weak carcinogen azoxymethane (AOM) the mice develop intestinal tumors. Our results identify sets of differentially expressed genes which are correlated with methylation changes of the corresponding genes. Whole transcriptome analysis of Mus musculus. Three conditions were sequenced and analyzed, the first is an untreated control, the second corresponds to inflammation induced by applying DSS, the third to cancer induced by inflammation and application of AOM. The control condition as well as the AOM-induced cancer condition were analyzed using three replicates, the second condition using 4 replicates.

2015-06-17 | E-GEOD-57533 | biostudies-arrayexpress

Altered epigenetic programming links intestinal inflammation to colon cancer (RNA-seq)

2015-06-17 | GSE57533 | GEO

Altered expression of Butyrophilin (<i>BTN</i>) and BTN-like (<i>BTNL</i>) genes in intestinal inflammation and colon cancer.

Project description: Not available

| S-EPMC4879465 | biostudies-literature

Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors.

Project description: Not available

| S-EPMC6041131 | biostudies-literature

Epigenetic differences in normal colon mucosa of cancer patients suggest altered dietary metabolic pathways.

Project description: Not available

| S-EPMC3294197 | biostudies-literature