Genomics

Dataset Information

175

Genome-wide occupancy of RNA polymerase II before and after heat shock in mouse cells


ABSTRACT: The goal of this study was to understand changes that occur in RNA polymerase II occupancy upon heat shock using ChIP-seq in mouse cells. Overall design: ChIP-seq of Pol II from control cells (no heat shock) and heat shocked cells. Input chromatin before and after heat shock was also sequenced.

REANALYSED by: GSE66487

INSTRUMENT(S): Illumina Genome Analyzer IIx (Mus musculus)

SUBMITTER: Jennifer F Kugel 

PROVIDER: GSE66513 | GEO | 2015-12-30

SECONDARY ACCESSION(S): PRJNA277185

REPOSITORIES: GEO

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Publications

Infection by Herpes Simplex Virus 1 Causes Near-Complete Loss of RNA Polymerase II Occupancy on the Host Cell Genome.

Abrisch Robert G RG   Eidem Tess M TM   Yakovchuk Petro P   Kugel Jennifer F JF   Goodrich James A JA  

Journal of virology 20151216 5


Lytic infection by herpes simplex virus 1 (HSV-1) triggers a change in many host cell programs as the virus strives to express its own genes and replicate. Part of this process is repression of host cell transcription by RNA polymerase II (Pol II), which also transcribes the viral genome. Here, we describe a global characterization of Pol II occupancy on the viral and host genomes in response to HSV-1 infection using chromatin immunoprecipitation followed by deep sequencing (ChIP-seq). The data  ...[more]

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