Genomics

Dataset Information

21

RNA Expression Profile of Calcified Bicuspid, Tricuspid and Normal Human Aortic Valves by RNA Sequencing


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)

SUBMITTER: Sandra Guauque-Olarte  

PROVIDER: GSE76718 | GEO | 2016-09-22

SECONDARY ACCESSION(S): GSE76717S-EPMC6195654PRJNA308447 GSE76712

REPOSITORIES: GEO

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Publications

RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencing.

Guauque-Olarte Sandra S   Droit Arnaud A   Tremblay-Marchand Joël J   Gaudreault Nathalie N   Kalavrouziotis Dimitri D   Dagenais Francois F   Seidman Jonathan G JG   Body Simon C SC   Pibarot Philippe P   Mathieu Patrick P   Bossé Yohan Y  

Physiological genomics 20160805 10


The molecular mechanisms leading to premature development of aortic valve stenosis (AS) in individuals with a bicuspid aortic valve are unknown. The objective of this study was to identify genes differentially expressed between calcified bicuspid aortic valves (BAVc) and tricuspid valves with (TAVc) and without (TAVn) AS using RNA sequencing (RNA-Seq). We collected 10 human BAVc and nine TAVc from men who underwent primary aortic valve replacement. Eight TAVn were obtained from men who underwent  ...[more]

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