Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GNPS - Methanobacter - Natural Product screen

ABSTRACT: Non-targted LC-MS/MS natural product screening of methane bacterium.

INSTRUMENT(S): Q-Exactive

ORGANISM(S): Methanobacterium (ncbitaxon:2160)

SUBMITTER: Aaron Puri

PROVIDER: MSV000080974 | GNPS | Thu Apr 20 21:44:00 BST 2017

REPOSITORIES: GNPS

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

GNPS - Methylobacter Natural Product Discovery

Project description:Non-targted MS/MS screening and structure elucidation of natural products from Methylobacter tundripaludum.

| MSV000081064 | GNPS

GNPS - Non-targted MS/MS Natural Product Screening of Pseudomonas strains

Project description:Non-targted MS/MS Natural Product Screening of three bacterial isolates of the genus Pseudomonas, native from agricultural soils in Argentina, that produce surfactant molecules. Pseudomonas chlororaphis SMMP3 Pseudomonas sp. SVMP4 Pseudomonas sp. SBMP6

2020-02-26 | MSV000085024 | GNPS

Effect of a natural product derivative on gene expression signatures in 5xFAD transgenic mice

Project description:To investigate how a natural product analog mitigates AD, cortical transcriptomes from WT and 5xFAD mice were analyzed. Comparing vehicle-treated groups revealed extensive differential expression associated with neuroinflammation in 5xFAD mice. This was attenuated in the 5xFAD mice treated with the natural product, whose profiles resembled WT controls. RNA seq suggested the natural product regulated the nervous and immune systems.

2025-05-13 | GSE296886 | GEO

A non-canonical transcriptional regulation in natural product biosynthesis

Project description:TenA-family proteins are widespread bacterial regulators with unknown roles in natural product biosynthesis. This study aimed to functionally characterize LysR2, a TenA-family protein in Actinobacteria, and elucidate its mechanism in regulating the production of lysolipin I. We demonstrate that LysR2 represents a novel type of regulator that controls antibiotic biosynthesis not by direct DNA binding, but through protein-protein interactions, specifically by antagonizing the repressor LysR1. This work reveals an unconventional regulatory strategy, expanding the mechanistic understanding of transcriptional networks in natural product formation.

2025-09-30 | GSE309193 | GEO

The marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway

Project description:The marine natural product honaucin A attenuates inflammation by activating the Nrf2-ARE pathway

2017-06-12 | GSE93558 | GEO

A non-canonical transcriptional regulation in natural product biosynthesis

Project description:A non-canonical transcriptional regulation in natural product biosynthesis

| PRJNA1334305 | ENA

Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis

Project description:Streptomyces has the largest repertoire of natural product biosynthetic gene clusters (BGCs), yet developing a universal engineering strategy for each Streptomyces species is challenging. Given that some Streptomyces species have larger BGC repertoires than others, we hypothesized that a set of genes co-evolved with BGCs to support biosynthetic proficiency must exist in those strains, and that their identification may provide universal strategies to improve the productivity of other strains. We show here that genes co-evolved with natural product BGCs in Streptomyces can be identified by phylogenomics analysis. Among the 597 genes that co-evolved with polyketide BGCs, 11 genes in the “coenzyme” category have been examined, including a gene cluster encoding for the co-factor pyrroloquinoline quinone (PQQ). When the pqq gene cluster was engineered into 11 Streptomyces strains, it enhanced production of 16,385 metabolites, including 36 known natural products with up to 40-fold improvement and several activated silent gene clusters. This study provides a new engineering strategy for improving polyketide production and discovering new biosynthetic gene clusters.

2024-03-01 | GSE256209 | GEO

Antimalarial mechanism of action of the natural product 9-methoxystrobilurin G

Project description:Antimalarial mechanism of action of the natural product 9-methoxystrobilurin G

2024-09-11 | PXD053143 | Pride

The natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa

Project description:Natural products represent a rich source for antibiotics addressing versatile cellular targets. The deconvolution of their targets via chemical proteomics is often challenged by the introduction of large photocrosslinkers. Here we select elegaphenone, a largely uncharacterized natural product antibiotic bearing a native benzophenone core scaffold, for affinity-based protein profiling (AfBPP) in Gram-positive and Gram-negative bacteria. This study utilizes the alkynylated natural product scaffold as a probe to uncover intriguing biological interactions with the transcriptional regulator AlgP. Furthermore, proteome profiling of a Pseudomonas aeruginosa AlgP transposon mutant revealed unique insights into the mode of action. Elegaphenone enhanced the killing of intracellular P. aeruginosa in macrophages exposed to sub-inhibitory concentrations of the fluoroquinolone antibiotic norfloxacin.

2021-09-08 | PXD010476 | Pride

GNPS - Non-targeted Metabolomics Plant Microbiome Screen

Project description:Non-targeted LC-MS/MS based Metabolomics of Plant Microbiome strain for natural product Screening

| MSV000095148 | GNPS