The natural product elegaphenone potentiates antibiotic effects against Pseudomonas aeruginosa
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Enterococcus Faecalis (streptococcus Faecalis)
SUBMITTER: 
Weining Zhao
LAB HEAD: Stephan Axel Sieber
PROVIDER: PXD010476 | Pride | 2021-09-08
REPOSITORIES: Pride
Publications
The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa.
Zhao Weining W Cross Ashley R AR Crowe-McAuliffe Caillan C Weigert-Munoz Angela A Csatary Erika E EE Solinski Amy E AE Krysiak Joanna J Goldberg Joanna B JB Wilson Daniel N DN Medina Eva E Wuest William M WM Sieber Stephan A SA
Angewandte Chemie (International ed. in English) 20190516 25
Natural products represent a rich source of antibiotics that address versatile cellular targets. The deconvolution of their targets via chemical proteomics is often challenged by the introduction of large photocrosslinkers. Here we applied elegaphenone, a largely uncharacterized natural product antibiotic bearing a native benzophenone core scaffold, for affinity-based protein profiling (AfBPP) in Gram-positive and Gram-negative bacteria. This study utilizes the alkynylated natural product scaffo ...[more]
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