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New antimicrobial agents development

ABSTRACT: With the growing antibiotic resistance of Staphylococcus aureus, it is urgent to discover new antimicrobials to solve this problem. By bacterial growth based high-throughput screening, we identified two compounds, C218-0546 and STK848198, with effective antimicrobial activity against S. aureus. This study aims to explore the model of action of the compounds by transcriptomic analysis and other microbiological methods. The transcriptomic data would provide us information about the regulated genes, and hence help us further study the underlying antimicrobial mechanisms by the compounds.

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Yong Wu

PROVIDER: PXD052423 | iProX | Mon May 20 00:00:00 BST 2024

REPOSITORIES: iProX

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Novel antibiotics against Staphylococcus aureus without detectable resistance by targeting proton motive force and FtsH.

Pengfei She S Yifan Yang Y Linhui Li L Yimin Li L Dan Xiao X Shaowei Guo G Guanqing Huang H Yong Wu W

MedComm 20250108 1

The increased prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and its biofilms poses a great threat to human health. Especially, S. aureus-related osteomyelitis was hardly cured even by conventional antibiotics combined with surgical treatment. The development of novel structural antibiotics is urgently needed. By high-throughput screening and rational design, we identified a small molecule C218-0546 and its optimized analog STK848198 with great antimicrobial poten ...[more]

PMID: 39781293

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