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Plasma metabolites of lipid metabolism associate with diabetic polyneuropathy in a cohort with screen-tested type 2 diabetes: ADDITION-Denmark

ABSTRACT: The global rise in type 2 diabetes (T2D) is associated with a concomitant increase in diabetic complications. Diabetic polyneuropathy (DPN), the most frequent T2D complication, is characterized by sensory peripheral nerve damage. Although managing glucose effectively slows DPN progression in type 1 diabetes patients, it has limited efficacy in neuropathic T2D patients. The metabolic syndrome (MetS) recently emerged as a major risk factor for DPN; however, the metabolites associated with MetS that correlate with DPN are unknown. We conducted a global plasma metabolomics analysis from a cohort of patients enrolled in the Anglo-Danish-Dutch study of Intensive Treatment of Diabetes in Primary Care (ADDITION), including healthy control subjects, T2D patients, and T2D DPN patients. We identified 15 total plasma metabolites that were altered in T2D DPN patients, including lipids, amino acids, and energy-related metabolites. We evaluated the correlation between these metabolites and all lipid species to identify major changes in both plasma free fatty acids and complex lipids in T2D DPN patients, and found significant alterations in the abundance of long-chain saturated fatty acids, acylcarnitines, and sphingolipids. Our study suggests that DPN in T2D is associated with novel alterations in plasma metabolites related to lipid metabolism.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Blood

DISEASE(S): Obesity

SUBMITTER: Eva Feldman

PROVIDER: ST001411 | MetabolomicsWorkbench | Mon Jun 22 00:00:00 BST 2020

REPOSITORIES: MetabolomicsWorkbench

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