Project description:Total RNA isolated from maternal serum (drawn between 36-37 weeks gestation)from pregnancies with a growth restricted infant defined as an Individualised birthweight centile (IBC) < 3rd matched to a control pregnancy (IBC 20-80th), n=4 per group with 2 female and 2 male infants per group. Maternal serum miRNAs profiled using miRCURY LNA Universal RT miRNA PCR Human panel I + II to determine biomarker potential for prediction of growth restriction and sexually dimorphic patterns.
Project description:The aim of this study was to establish the exosomal miRNA profile across gestation in normal and GDM pregnancies and to determine the signaling pathways associated with the changes in the miRNA profile in GDM.
Project description:In this study, we provide evidence that ischemic exercise, conducted as blood flow-restricted resistance exercise, promote changes in the micro-RNA cargo of circulating extracellular vesicles in healthy volunteers.