Dataset Information
Cooperative action of NC2 and Mot1p to regulate TATA-binding protein function across the genome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ FT, instrument model
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: 
Maarten Altelaar
PROVIDER: PRD000050 | Pride | 2008-07-17
REPOSITORIES: Pride
Publications
Cooperative action of NC2 and Mot1p to regulate TATA-binding protein function across the genome.
Genes & development 20080814 17
Promoter recognition by TATA-binding protein (TBP) is an essential step in the initiation of RNA polymerase II (pol II) mediated transcription. Genetic and biochemical studies in yeast have shown that Mot1p and NC2 play important roles in inhibiting TBP activity. To understand how TBP activity is regulated in a genome-wide manner, we profiled the binding of TBP, NC2, Mot1p, TFIID, SAGA, and pol II across the yeast genome using chromatin immunoprecipitation (ChIP)-chip for cells in exponential gr ...[more]
