Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human) Bos Taurus (bovine)
TISSUE(S): Blood Platelet
SUBMITTER: Christian Toonstra
LAB HEAD: Hui Zhang
PROVIDER: PXD010290 | Pride | 2019-06-14
REPOSITORIES: Pride
Toonstra Christian C Hu Yingwei Y Zhang Hui H
Journal of proteome research 20190515 6
Collagen is a potent agonist for platelet activation, presenting itself as a key contributor to coagulation via interactions with platelet glycoproteins. The fine details dictating platelet-collagen interactions are poorly understood. In particular, glycosylation could be a key determinant in the platelet-collagen interaction. Here, we report an affinity purification coupled to a mass spectrometry-based approach to elucidate the function of N-glycans in dictating platelet-collagen interactions. ...[more]