Proteomics

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NanoToxClass: Investigation of dose-dependent nanomaterial effects after instillations with rats

ABSTRACT: In this study, rats were exposed to three different doses of nanomaterials (SiO2_15_Amino, SiO2_15_Unmod, SiO2_7, SiO2_40) using instillations. Effects on exposure and recovery groups were compared using untargeted proteomics.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Lung

SUBMITTER: Isabel Karkossa  

LAB HEAD: Kristin Schubert

PROVIDER: PXD020184 | Pride | 2021-09-29

REPOSITORIES: Pride

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Nanomaterials induce different levels of oxidative stress, depending on the used model system: Comparison of in vitro and in vivo effects.

Karkossa Isabel I   Bannuscher Anne A   Hellack Bryan B   Wohlleben Wendel W   Laloy Julie J   Stan Miruna S MS   Dinischiotu Anca A   Wiemann Martin M   Luch Andreas A   Haase Andrea A   von Bergen Martin M   Schubert Kristin K  

The Science of the total environment 20210808

The immense diversity and constant development of nanomaterials (NMs) increase the need for a facilitated risk assessment, which requires knowledge of the modes of action (MoAs) of NMs. This necessitates a comprehensive data basis, which can be obtained using omics. Furthermore, the establishment of suitable in vitro test systems is essential to follow the 3R concept and to cope with the high number of NMs. In the present study, we aimed to compare NM effects in vitro and in vivo using a multi-o  ...[more]

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