Arterial-Venous Endothelial Cell Cycle Proteins Differential Expression

ABSTRACT: HUVEC-FUCCI cells were used to demonstrate that different endothelial cell cycle states provide distict windows of opportunity for gene expression in response to extrinsic signals. HUVEC-FUCCI were FACS-isolated into three different cell cycle states. Peptide digests from the resulting lysates showed differentially expressed proteins among the three cell cycles. These studies show that endothelial cell cycle state determines the propensity for arterial vs. venous fate specification.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Endothelial Cell Of Umbilical Vein, Cell Culture

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Erin Jeffery  

LAB HEAD: Dr. Gloria Sheynkman

PROVIDER: PXD036326 | Pride | 2022-10-12

REPOSITORIES: Pride