Dataset Information
K63 polyubiquitin targets in the amygdala across the lifespan
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Brain, Amygdala
SUBMITTER: 
Keith Ray
LAB HEAD: Timothy J. Jarome
PROVIDER: PXD058253 | Pride | 2025-06-18
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 240730_Jarome_A1_01.msf | Msf | |||
| 240730_Jarome_A1_01.msfView | Msf | |||
| 240730_Jarome_A1_01.mzML | Mzml | |||
| 240730_Jarome_A1_01.mzid.gz | Mzid | |||
| 240730_Jarome_A1_01.pdResult | Other |
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Publications
Age-related dysregulation of proteasome-independent K63 polyubiquitination in the hippocampus and amygdala.
Neuroscience 20250614
Cognitive decline with aging is a complex process involving multiple brain regions and molecular mechanisms. While the role of the canonical protein degradation function of the ubiquitin-proteasome system (UPS) has been well studied in the context of aging and age-associated memory loss, the non-proteolytic functions of ubiquitin activity remain poorly understood. Here, we investigated the role of lysine-63 (K63) polyubiquitination, the most abundant form of proteasome-independent ubiquitination ...[more]