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Characterization of the adsorbed protein layer on orthopedic biomaterials and regenerative effects after the first patient contact

ABSTRACT: In this study, we investigate the intraoperative protein adsorption on the synthetic bone substitutes β-TCP (tricalcium phosphate) and PCL (polycaprolactone) using two different adsorption techniques.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Farnusch Kaschani

LAB HEAD: Farnusch Kaschani

PROVIDER: PXD066010 | Pride | 2025-10-06

REPOSITORIES: Pride

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			Action	DRS
	ACE_0943_AS01.raw	Raw
	ACE_0943_AS02.raw	Raw
	ACE_0943_AS03.raw	Raw
	ACE_0943_AS04.raw	Raw
	ACE_0943_AS05.raw	Raw

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Publications

Intraoperative Biologization of β-TCP and PCL-TCP by Autologous Proteins.

Sowislok Andrea A Gruber Gerrit G Kaschani Farnusch F Kaiser Markus M Papaeleftheriou Eleftherios E Jäger Marcus M

Journal of functional biomaterials 20250909 9

Protein adsorption on orthopedic biomaterials during the initial intraoperative contact critically influences biological responses and osseointegration. Osteoconductive grafts such as β-tricalcium phosphate (β-TCP) and poly (ε-caprolactone)-β-TCP (PCL-TCP) can be functionally activated by exposure to autologous tissue. However, the composition and relevance of the resulting protein layer still remain unclear. In this study involving 10 patients undergoing primary total hip arthroplasty, β-TCP an ...[more]

PMID: 41003411

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