Dataset Information
BioID-MS identification of WDR62 binding partners.
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Early Embryonic Cell
DISEASE(S): Neuroblastoma
SUBMITTER: 
Dominic Ng
LAB HEAD: Dominic Chi Hiung Ng
PROVIDER: PXD074147 | Pride | 2026-04-06
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20160113_Yvonne_Y1.group | Other | |||
| 20160113_Yvonne_Y10B.group | Other | |||
| 20160113_Yvonne_Y10B__FDR.xlsx | Xlsx | |||
| 20160113_Yvonne_Y1__FDR.xlsx | Xlsx | |||
| 20160113_Yvonne_Y2.group | Other |
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Publications
Microcephaly-associated protein WDR62 supports purine metabolism by interacting with co-chaperone BAG2.
The EMBO journal 20260305 7
Inherited mutations in the spindle pole-associated scaffold protein WDR62 cause autosomal recessive primary microcephaly. Previous research has characterised the roles of WDR62 in the regulation of spindle dynamics, cell division, and brain development. Here, we identify a new function of this protein in regulating purine metabolism. WDR62 interacts directly with BAG2, a co-chaperone of HSP70/90. Under stress conditions, WDR62 and BAG2 re-localise to cytoplasmic granules enriched for enzymes inv ...[more]