Project description:Ezh2-cKO or Utx-cKO in chondrocytes initiate metachondromatosis which containing both exostoses and enchondromas. To figure out whether the exostoses of Ezh2-cKO and Utx-cKO were the similar tumore, we compared the transcriptional profiles using RNA-sequencing of exostoses from Ezh2-cKO and Utx-cKO mice.
Project description:We collected whole genome testis expression data from hybrid zone mice. We integrated GWAS mapping of testis expression traits and low testis weight to gain insight into the genetic basis of hybrid male sterility.
Project description:ChIP-seq analysis of H3K4me3 and H3K27me3 histone modification in MBT2 cell lines transfected pX330 vector with Utx-targeted sgRNA ( KO) or without Utx-targeted sgRNA ( EV)
Project description:Transcriptome analysis of hematopoietic stem/progenitor cells (HSPCs) from control and Jmjd3 cKI mice (Jmjd3 cKI HSPCs vs control HSPCs)