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Bacterial diversity study from mice fed normal diet (ND), high fat diet (HFD) or HFD supplemented with KFLAB (HFD-KFLAB)

ABSTRACT: Pyrosequencing analysis of microbial communities of mice fed normal diet (ND), high fat diet (HFD) or HFD supplemented with KFLAB (HFD-KFLAB) using 454 GS FLX Titanium System

PROVIDER: PRJEB2698 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR047467.fastq.gz	Fastqsanger.gz
	ERR047468.fastq.gz	Fastqsanger.gz
	ERR047469.fastq.gz	Fastqsanger.gz
	ERR047470.fastq.gz	Fastqsanger.gz
	ERR047471.fastq.gz	Fastqsanger.gz

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C57BL/6J WT mice liver and adipose: normal diet (ND) vs. high-fat diet (HFD)

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RNAseq of mRNA from splenic and hepatic CD8 T cells in ND and CD-HFD mice

Project description:In this study we want to compare the gene expression profile of CD44+CXCR6+ CD8+ T cells from the liver of ND and CD-HFD mice with hepatic CD44+CXCR6neg and splenic CD44+ CX3CR1neg CD8 T cells of ND and CD-HFD mice. This comparison will reveal transcriptional signatures of hepatic CD44+CXCR6+ CD8+ T cells in CD-HFD responsible for causing liver pathology in NASH.

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Project description:In order to establish an obese mouse model, female mice were continuously fed with a high-fat diet (HFD) or a normal diet (control) for 16 weeks beginning at three weeks of age. In this paper, these mice are termed ‘HFD mice’ and ‘control mice’, respectively. Accordingly, we call their oocytes ‘HFD oocytes’ and ‘control oocytes’. Substantial evidence indicates that the effects of maternal obesity on embryo/offspring development can be attributed to factors within the oocyte (9). To identify such potential effectors, we performed a comparative proteomic analysis of ovulated MII oocytes from control and HFD mice.

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Gene expression data of livers from C57BL/6 fed a normal diet or high-fat-diet

Project description:Obesity is tightly associated with an increased risk of nonalcoholic fatty liver disease (NAFLD). However, the molecular mechanisms of obesity-induced fatty liver remain largely unknown.In order to identify genes that are potentially involved in dysfunctional hepatic lipid homeostasis in obesity, we performed a clustering analysis of Affymetrix arrays,which revealed that a number of mRNAs were dys-regulated in the livers of mice fed a high-fat diet (HFD), compared with mice fed a normal chow diet (ND). To identify genes that are potentially involved in dysfunctional hepatic lipid homeostasis in obesity, male C57BL/6 mice aged 8 weeks were fed a normal diet (ND) or high-fat-diet (HFD) containing 60 Kcal% of fat for 12 weeks. Then mice were sacrificed and total RNAs were isoloated from hepatic tissues. Affymetrix array hybridisation and scanning were performed using Mouse Genome 430 2.0 chips.Total RNA samples obtained from six mice per group (ND and HFD) and pooled by each of the two were used for microarray analysis.

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Comparative transcriptomic profiling of liver tissue from wild-type C57BL-6 mice fed a high-fat diet (HFD) supplemented with the probiotic (P) Bifidobacterium pseudocatenulatum CECT 7765.

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Expression data for eidididymal fat from high fat diet mice.

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High Fat Diet (HFD)-Induced Obesity Augments the Deleterious Effects of Estrogen Deficiency on Bone: Evidence from ovariectomized Mice.

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